The global structure (Pert diagram) of the project is presented here under. Five workpackages (WP) have been defined, each addressing specific enzymatic reactions (WPs 1 and 2), or parts of a biosynthetic pathway (WPs 3 and 4, divided according to the cellular location of the enzymes) or a complex cellular process and its control (WP5). The latter WP also aims at integrating the data obtained in the others, so that a general but detailed picture of cell growth and division will be obtained. In WPs 3, 4 and 5, particular reactions or interactions will be identified as especially amenable to interference by an inhibitor which will become a lead compound in the search for new antibiotics. The workpackages are subject-oriented.
The project is financed by the European Commission under The Sixth Research Framework Programme and coordinated by the University of Liege through The Center for Protein Engineering.