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Objectives
Project Summary
Five workpackages (WP) will provide converging approaches to the same general goal.
- The study and the design of inhibitors for penicillin-resistant transpeptidases.
- The development of inhibitors of the glycosyltransferase domain of class A penicillin-binding proteins.
- The study and the design of inhibitors for the synthesis and transport steps of cell wall subunits located at the plasma membrane.
- The study and the design of inhibitors for the synthesis of soluble peptidoglycan precursors.
- The study of cell morphogenesis and of its regulation and the design of compounds which might interfere with these processes.
This ambitious project will lead to new insights into bacterial physiology and might have a pronounced impact in other areas including biotechnology, and bacterial pathogenesis. Indeed, this project will create renewed interest in these key areas and pave the way to innovative solutions for fighting resistance to antibiotics.
The project is financed by the European Commission under The Sixth Research Framework Programme and coordinated by the University of Liege through The Center for Protein Engineering.